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Zhonghua Nei Ke Za Zhi. 1999 Sep;38(9):622-4.

[A clinical trial of 14 and 15 membered macrolides in treating six cases of diffuse panbronchiolitis].

[Article in Chinese]

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  • 1Department of Pulmonary Medicine, Chinese PLA General Hospital, Beijing 100853.



To observe the therapeutic effect of macrolides in treating diffuse panbronchiolitis (DPB).


14- and 15-ring macrolides were used in the treatment of six confirmed cases of DPB for 3 approximately 24 months. The improvement in symptoms, X-ray findings, lung function and results of blood gas analysis was recorded.


Symptoms such as cough, sputum expectoration and exertional dyspnea alleviated significantly during the first 2 weeks. PaO(2) level, FEV(1)%, and vital capacity (VC) increased remarkably. Diffuse small nodular lesions on chest X-ray or CT decreased in size within a few months.


Macrolides have significant therapeutic effect on DPB and the patients have good tolerance to them. However, the mechanism of its action, the selection of the best macrolide, the most suitable dosage and the appropriate period of treatment still need further investigation.

[PubMed - indexed for MEDLINE]
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