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Zhonghua Nei Ke Za Zhi. 1999 Jan;38(1):14-7.

[Effect of mecobalamin on diabetic neuropathies. Beijing Methycobal Clinical Trial Collaborative Group].

[Article in Chinese]

Author information

1
Department of Endocrinology, China-Japan Friendship Hospital, Beijing 100029.

Abstract

OBJECTIVE:

To investigate the effect of mecobalamin on diabetic neuropathies.

METHODS:

One hundred and eight patients with non-insulin dependent diabetes mellitus were involved in a randomized positive-control clinical trial. 62 cases were treated with mecobalamin 500 microg intramuscularly three times a week for four weeks then followed by 500 microg orally three times a day for additional eight weeks. 46 cases were treated with vitamin B(12) in the same way and served as controls.

RESULTS:

Twelve weeks after the treatment, spontaneous pain and numbness of limbs were improved by 73% and 75% in the mecobalamin group, which were much higher than those in the controls (36% and 45% respectively). Hypoesthesia, hotness, coldness, oral dryness and dysuria showed better response in the mecobalamin group than in the controls (55% vs 25%, 52% vs 18%, 59% vs 30%, 53% vs 19%, 63% vs 20% respectively). Mecobalamin also benefited nerve reflection and conduction velocity to a certain extent. No obvious side effects were found.

CONCLUSION:

Mecobalamin might be worthy of use as a safe agent in the treatment of diabetic neuropathies.

PMID:
11798619
[Indexed for MEDLINE]

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