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IUBMB Life. 2001 Sep-Nov;52(3-5):119-28.

Respiratory chain supercomplexes.

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1
Zentrum der Biologischen Chemie, Universitätsklinikum Frankfurt, Frankfurt am Main, Germany. schagger@zbc.klinik.uni-frankfurt.de

Abstract

Respiratory chain supercomplexes have been isolated from mammalian and yeast mitochondria, and bacterial membranes. Functional roles of respiratory chain supercomplexes are catalytic enhancement, substrate channelling, and stabilization of complex I by complex III in mammalian cells. Bacterial supercomplexes are characterized by their relatively high detergent-stability compared to yeast or mammalian supercomplexes that are stable to sonication. The mobility of substrate cytochrome c increases in the order bacterial, yeast, and mammalian respiratory chain. In bacterial supercomplexes, the electron transfer between complexes III and IV involves movement of the mobile head of a tightly bound cytochrome c, whereas the yeast S. cerevisiae seems to use substrate channelling of a mobile cytochrome c, and mammalian respiratory chains have been described to use a cytochrome c pool. Dimeric ATP synthase seems to be specific for mitochondrial OXPHOS systems. Monomeric complex V was found in Acetobacterium woodii and Paracoccus denitrificans.

PMID:
11798023
DOI:
10.1080/15216540152845911
[Indexed for MEDLINE]
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