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Endocrinology. 2002 Feb;143(2):726-9.

Ghrelin and leptin pulse discharge in fed and fasted rats.

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Department of Neuroscience, College of Medicine, University of Florida, McKnight Brain Institute, Gainesville, Florida 32610-0244, USA.


Ghrelin stimulates and leptin inhibits appetite by modulating neuropeptide Y (NPY) signaling in the hypothalamus. Analysis of plasma ghrelin and leptin by sensitive radioimmunoassays showed that the two peripheral hormones are secreted in pulsatile fashion in rats consuming ad libitum rat chow. Fasting augmented all parameters of ghrelin pulsatile secretion and diminished leptin secretion by selectively attenuating the pulse amplitude; concomitantly it produced synchrony in ghrelin and leptin pulse discharge. These studies imply that a synchronous leptin restraint and ghrelin stimulus on NPYergic signaling may underlie robust appetitive drive.

[Indexed for MEDLINE]

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