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Trends Cardiovasc Med. 2002 Jan;12(1):32-7.

Calmodulin is a limiting factor in the cell.

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  • 1School of Biological Sciences, Division of Molecular Biology & Biochemistry, University of Missouri-Kansas City, Kansas City, MO 64110-2499, USA.


The total intracellular concentration of calmodulin (CaM) in the cell appears to be significantly below the total concentration of its targets, making it a limiting factor in their regulation. In this review we discuss the ways in which this is likely to impact signaling. A key conclusion is that competition for a limiting pool of CaM enables cross-talk between CaM-dependent signaling pathways.

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