Format

Send to

Choose Destination
Arch Biochem Biophys. 2002 Jan 15;397(2):172-8.

Peptide methionine sulfoxide reductase: structure, mechanism of action, and biological function.

Author information

1
Center for Molecular Biology and Biotechnology, Florida Atlantic University, Boca Raton, Florida 33431, USA. hweissba@fau.edu

Abstract

Reactive oxygen and nitrogen intermediates can cause damage to many cellular components and have been implicated in a number of diseases. Cells have developed a variety of mechanisms to destroy these reactive molecules or repair the damage once it occurs. In proteins one of the amino acids most easily oxidized is methionine, which is converted to methionine sulfoxide. An enzyme, peptide methionine sulfoxide reductase (MsrA), catalyzes the reduction of methionine sulfoxide in proteins back to methionine. There is growing evidence that MsrA plays an important role in protecting cells against oxidative damage. This paper reviews the biochemical properties and biological role of MsrA.

PMID:
11795868
DOI:
10.1006/abbi.2001.2664
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center