Send to

Choose Destination
Ann N Y Acad Sci. 2001 Dec;952:109-15.

Inhibition of cyclooxygenase-2: an approach to preventing cancer of the upper aerodigestive tract.

Author information

Department of Medicine, New York Presbyterian Hospital and Weill Medical College of Cornell University, New York 10021, USA.


Multiple lines of evidence suggest that cyclooxygenase-2 (COX-2), an inducible form of COX, represents a potential pharmacologic target to prevent cancer. Key data suggesting a causal relationship between increased COX-2 activity and carcinogenesis and possible mechanisms of action of COX-2 in this context will be discussed. The possibility that COX-2 represents a pharmacological target for preventing upper aerodigestive cancers (head and neck, lung) will be emphasized. Importantly, clinical trials have been initiated to assess the chemopreventive properties of selective COX-2 inhibitors.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center