Format

Send to

Choose Destination
Ann N Y Acad Sci. 2001 Dec;952:109-15.

Inhibition of cyclooxygenase-2: an approach to preventing cancer of the upper aerodigestive tract.

Author information

1
Department of Medicine, New York Presbyterian Hospital and Weill Medical College of Cornell University, New York 10021, USA. ajdannen@med.cornell.edu

Abstract

Multiple lines of evidence suggest that cyclooxygenase-2 (COX-2), an inducible form of COX, represents a potential pharmacologic target to prevent cancer. Key data suggesting a causal relationship between increased COX-2 activity and carcinogenesis and possible mechanisms of action of COX-2 in this context will be discussed. The possibility that COX-2 represents a pharmacological target for preventing upper aerodigestive cancers (head and neck, lung) will be emphasized. Importantly, clinical trials have been initiated to assess the chemopreventive properties of selective COX-2 inhibitors.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center