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Ann N Y Acad Sci. 2001 Dec;953:157-64.

Pharmacological issues in the treatment of tuberculosis.

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Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA.


A thorough review of the clinical trial data combined with new in vitro experimental information may make the optimization of dosages of TB drugs possible. Several factors can affect the selection and dosage of TB drugs including hepatic and renal impairment, pregnancy, duration of disease before treatment, and extent of debilitation. Drug interactions and pharmacodynamics must be considered, and their roles are discussed.

[Indexed for MEDLINE]

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