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Leuk Res. 2002 Mar;26(3):241-8.

High serum soluble CD44 is correlated with a poor outcome of aggressive non-Hodgkin's lymphoma.

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Department of Hematology and Internal Medicine, Internal Medicin IV, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara-Shi, Kanagawa 228-8555, Japan.


We measured soluble CD44 (sCD44) by enzyme-linked immunosorbent assay in 216 patients with non-Hodgkin's lymphoma (NHL). The sCD44 level was significantly elevated in patients with NHL. A sCD44 level of > or =500 ng/ml showed a significantly decreased overall survival (OS) rate and progression free survival (PFS) rate. In the high-intermediate+high risk group (international prognostic index (IPI)), both the OS rate and the PFS rate were significantly decreased when the sCD44 level was > or =1000 ng/ml. Moreover, the results of a multivariate analysis showed that the five IPI prognostic factors and the sCD44 level were independent prognostic factors, thus suggesting that sCD44 levels could be a useful prognostic marker for aggressive lymphoma.

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