Synthesis of blood compatible polyamide block copolymers

Biomaterials. 2002 Feb;23(4):1139-45. doi: 10.1016/s0142-9612(01)00228-9.

Abstract

Blood compatibility of polyamides has been improved by introducing amido-amine groups in polymer backbone. Polyamide block-copolymer are synthesized by reacting amine end-capped polyamides with N,N'-methylene-bisacrylamide. Polyamide block-copolymers, thus produced found to have the ability of absorbing heparin. Heparinized polyamide block-copolymers have shown significant improvement in blood compatibility as evident from thrombus formation and hemolysis studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemical synthesis*
  • Biocompatible Materials / chemistry
  • Blood*
  • Heparin
  • Humans
  • In Vitro Techniques
  • Materials Testing
  • Molecular Structure
  • Nylons / chemical synthesis*
  • Nylons / chemistry
  • Spectrum Analysis
  • Surface Properties
  • Thrombosis / prevention & control
  • X-Rays

Substances

  • Biocompatible Materials
  • Nylons
  • Heparin