Format

Send to

Choose Destination
See comment in PubMed Commons below
FASEB J. 2002 Mar;16(3):414-6. Epub 2002 Jan 14.

Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment.

Author information

1
VBC-GENOMICS, A-1030 Vienna, Austria.

Abstract

Type I allergy is an immunoglobulin E (IgE)-mediated hypersensitivity disease affecting more than 25% of the population. Currently, diagnosis of allergy is performed by provocation testing and IgE serology using allergen extracts. This process defines allergen-containing sources but cannot identify the disease-eliciting allergenic molecules. We have applied microarray technology to develop a miniaturized allergy test containing 94 purified allergen molecules that represent the most common allergen sources. The allergen microarray allows the determination and monitoring of allergic patients' IgE reactivity profiles to large numbers of disease-causing allergens by using single measurements and minute amounts of serum. This method may change established practice in allergy diagnosis, prevention, and therapy. In addition, microarrayed antigens may be applied to the diagnosis of autoimmune and infectious diseases.

PMID:
11790727
DOI:
10.1096/fj.01-0711fje
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Support Center