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Drug Discov Today. 2002 Jan 15;7(2):143-7.

Multi-component reactions and evolutionary chemistry.

Author information

1
Morphochem, Gmunderstr. 37, D-81379 M√ľnchen, Germany. lutz.weber@morphchem.de

Abstract

Multi-component reactions (MCRs) provide a new approach towards the efficient synthesis of diverse compounds and compound libraries. MCRs are evolving from being purely a chemistry curiosity to being recognized as having increasing relevance for drug discovery in terms of lead discovery and optimization. The combination of MCR-type chemistry-planning with evolutionary in silico and in vitro prediction of drug potential or biological properties is a new and powerful tool in drug discovery.

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PMID:
11790626
DOI:
10.1016/s1359-6446(01)02090-6
[Indexed for MEDLINE]

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