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Curr Opin Genet Dev. 2002 Feb;12(1):47-52.

Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes.

Author information

1
Howard Hughes Medical Institute, Department of Cellular and Molecular Medicine, UCSD, 9500 Gilman Drive, La Jolla, California 92093-0686, USA.

Abstract

Progression of resting quiescent G(0) cells into early G(1) and transition across the restriction point are highly regulated processes. Mutation of proto-oncogenes and tumor suppressor genes regulating these transitions are targeted during oncogenesis. Recent work has underscored the importance of the G(0) to early G(1) transition and metabolism to neoplastic cells.

PMID:
11790554
DOI:
10.1016/s0959-437x(01)00263-5
[Indexed for MEDLINE]

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