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Curr Opin Immunol. 2002 Feb;14(1):136-45.

Phagocytosis and innate immunity.

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Columbia University, Departments of Medicine and Pharmacology/BB914, 630 West 168th Street, New York, NY 10032, USA.


Phagocytosis is an evolutionarily conserved process utilized by many cells to ingest microbial pathogens, and apoptotic and necrotic corpses. Recent investigation has revealed a fundamental requirement for two co-ordinated cellular processes--cytoskeletal alterations and membrane trafficking--in the phagocytic event. Some elements of this machinery are co-opted by certain pathogens to gain entry into host cells.

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