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Curr Opin Immunol. 2002 Feb;14(1):136-45.

Phagocytosis and innate immunity.

Author information

1
Columbia University, Departments of Medicine and Pharmacology/BB914, 630 West 168th Street, New York, NY 10032, USA. greenberg@cuccfa.ccc.columbia.edu

Abstract

Phagocytosis is an evolutionarily conserved process utilized by many cells to ingest microbial pathogens, and apoptotic and necrotic corpses. Recent investigation has revealed a fundamental requirement for two co-ordinated cellular processes--cytoskeletal alterations and membrane trafficking--in the phagocytic event. Some elements of this machinery are co-opted by certain pathogens to gain entry into host cells.

PMID:
11790544
[Indexed for MEDLINE]

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