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Curr Opin Immunol. 2002 Feb;14(1):103-10.

Toll-like receptors: key mediators of microbe detection.

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Institute for Systems Biology, 4225 Roosevelt Way NE, Seattle, WA 98105, USA.


Toll-like receptors are pattern-recognition receptors that have key roles in detecting microbes and initiating inflammatory responses. Recently, a host of new microbial products that activate specific Toll-like receptors have been defined, and additional components that mediate intracellular signaling have been identified. There has also been greater recognition of the importance of specific Toll-like receptors in host defense.

[Indexed for MEDLINE]

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