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Curr Biol. 2002 Jan 8;12(1):R21-3.

EGF receptor signalling: roles of star and rhomboid revealed.

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1
Institut für Neuro- und Verhaltensbiologie, Universität Münster, 48149, Münster, Germany.

Abstract

Recent studies have clarified how the active form of the Drosophila EGF receptor ligand Spitz is produced: Star chaperones Spitz in the ER and mediates its transport to the Golgi, where the intramembrane serine protease Rhomboid cleaves the Spitz proprotein to initiate secretion.

PMID:
11790319
DOI:
10.1016/s0960-9822(01)00642-x
[Indexed for MEDLINE]
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