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Arch Neurol. 2002 Jan;59(1):128-34.

Correlation of diffusion-weighted magnetic resonance imaging with neuropathology in Creutzfeldt-Jakob disease.

Author information

1
Department of Neurology, North Shore University Hospital, 300 Community Dr, Manhasset, NY 11030, USA.

Abstract

BACKGROUND:

Although the diagnosis of Creutzfeld-Jakob disease (CJD) is straightforward in fully developed cases, a definitive diagnosis can be difficult early in the course of the illness. T2-weighted magnetic resonance imaging (MRI) signal abnormalities, and recently, diffusion-weighted MRI abnormalities, have been described in patients with CJD, suggesting the utility of MRI in the early recognition of CJD.

OBJECTIVE:

To correlate diffusion-weighted MRI signal abnormalities with neuropathologic changes in CJD.

MATERIALS AND METHODS:

Diffusion-weighted MRI and neuropathologic changes of 2 patients with autopsy-proven CJD were examined in a blinded fashion by a neuroradiologist and a neuropathologist.

RESULTS:

Areas of bright signal on diffusion-weighted MRI correlated with a higher degree of spongiform changes.

CONCLUSION:

Diffusion-weighted MRI in CJD demonstrates specific-signal abnormalities that correlate well with areas of the most severe and characteristic neuropathologic changes.

PMID:
11790240
DOI:
10.1001/archneur.59.1.128
[Indexed for MEDLINE]

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