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Obes Res. 2002 Jan;10(1):1-5.

Resistin gene expression in human adipocytes is not related to insulin resistance.

Author information

1
Franz Volhard Clinic-Charité, the Max Delbrück Center for Molecular Medicine, Berlin, Germany.

Abstract

OBJECTIVES:

Obesity is an important risk factor for the development of insulin resistance and type 2 diabetes. Recently, a newly described circulating hormone resistin, which is expressed primarily in adipocytes, has been shown to antagonize insulin action in mice. Resistin, therefore, has been suggested to play a role in the pathogenesis of insulin resistance.

RESEARCH METHODS AND PROCEDURES:

We studied the expression of the resistin gene in primary cultured human adipocytes and preadipocytes. We also examined resistin gene expression in subcutaneous abdominal adipocytes in women (n = 24) over a wide range of body weight and insulin sensitivity.

RESULTS:

Whereas resistin gene expression was barely detectable in mature adipocytes, it was highly expressed in preadipocytes. Adipogenic differentiation of preadipocytes was associated with a time-dependent down-regulation of resistin gene expression. There was no relationship between body weight, insulin sensitivity, or other metabolic parameters and adipocyte resistin gene expression in the clinical study.

DISCUSSION:

Together these findings do not support an important role of adipose-tissue resistin gene expression in human insulin resistance.

PMID:
11786595
DOI:
10.1038/oby.2002.1
[Indexed for MEDLINE]
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