Format

Send to

Choose Destination
Curr Opin Pharmacol. 2002 Feb;2(1):76-81.

Oligomerization of opioid receptors: generation of novel signaling units.

Author information

1
Department of Pharmacology, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada.

Abstract

G-protein-coupled receptors such as opioid receptors exist in oligomeric complexes. Homo-oligomerization of mu, delta, and kappa opioid receptors has been demonstrated, suggesting a critical functional role for receptor-receptor interactions. Hetero-oligomerization creates delta-kappa and mu-delta receptor complexes, which display novel pharmacology, coupling to effector systems and signaling regulation properties. Exciting new opportunities are arising from the recent characterization of these oligomeric receptors, with the potential to revolutionize opioid research and therapeutic targeting.

PMID:
11786312
DOI:
10.1016/s1471-4892(02)00124-8
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center