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J Biomech Eng. 2001 Dec;123(6):613-22.

Modeling modulus reduction in bovine trabecular bone damaged in compression.

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  • 1Division of Health Sciences and Technology, Harvard Medical School-Massachusetts Institute of Technology, Cambridge 02139, USA.


Loading bone beyond its yield point creates microdamage, leading to reduction in stiffness. Previously, we related microdamage accumulation to changes in mechanical properties. Here, we develop a model that predicts stiffness loss based on the presence of microdamage. Modeling is done at three levels: (1) a single trabecula, (2) a cellular solid consisting of intact, damaged, and fractured trabeculae, and (3) a specimen with a localized damage band. Predictions of a reduced modulus agree well with experimental measured modulus reductions of post-yield compression of bovine trabecular bone. The predicted reduced modulus is relatively insensitive to changes in the input parameters.

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