A new bicoumarin from Stellera chamaejasme L

J Asian Nat Prod Res. 2001;3(4):335-40. doi: 10.1080/10286020108040373.

Abstract

Thirteen compounds were isolated from roots of Stellera chamaejasme L. (Thymelaeaceae). They are 3-sitosterol (2), simplexin (3), pimelea factor P2 (4), daucosterol (5), (+)-3-hydroxy-1,5-diphenyl-1-pentanone (6), 4-ethoxy-benzoic acid (7), 2,4,6-Trimethoxy-benzoic acid (8), (+)-afzelechin (9), fumaric acid (10), N,N-dimethyl-L-aspartic acid (11), umbelliferone (12), daphniretin (13) and a novel bicoumarin named bicoumastechamin (1). Among the known compounds, 7, 8, 9, 10 and 11 were first isolated from this plant, and 6 was first isolated from the natural resources. Their structures have been elucidated on the basis of spectral data. In vitro bioassays showed that 4 inhibited cancer cell growth, 13 exhibited immunomodulatory activity, and 6 exhibited both immunomodulatory and anti-tumor activity.

MeSH terms

  • Chromatography, Gel
  • Coumarins / chemistry
  • Coumarins / isolation & purification*
  • Drugs, Chinese Herbal / chemistry
  • Magnetic Resonance Spectroscopy
  • Plant Roots / chemistry
  • Spectrophotometry, Infrared
  • Thymelaeaceae / chemistry*
  • Tumor Cells, Cultured

Substances

  • Coumarins
  • Drugs, Chinese Herbal
  • bicoumastechamin