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Brain Behav Immun. 2001 Dec;15(4):319-39.

Review of immunological and immunopathological findings in schizophrenia.

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1
Department of Psychiatry, University of Muenster, Muenster, Germany.

Abstract

The involvement of immunological and immunopathological mechanisms in the etiopathogenesis of schizophrenia has been a matter of research, with recently increasing effort. This article reviews the findings focusing on postmortem neuropathology, the blood-brain barrier, antibodies, acute phase proteins, immunocompetent cells, and activation markers of immunocompetent cells. Evidence for the two primarily postulated hypotheses (the infectious hypothesis and the autoimmune hypothesis) is critically discussed. On the basis of the findings, perspectives for future research are outlined aiming at a precise and consequent strategy to elucidate a potential involvement of immune mechanisms in the etiopathogenesis of schizophrenia.

PMID:
11782102
DOI:
10.1006/brbi.2001.0648
[Indexed for MEDLINE]
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