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Trends Biotechnol. 2001 Oct;19(10 Suppl):S17-22.

Matching peptide mass spectra to EST and genomic DNA databases.

Author information

1
Cell Mapping Project, GlaxoSmithKline R&D, Stevenage, UK.

Abstract

The use of mass spectrometry data to search molecular sequence databases is a well-established method for protein identification. The technique can be extended to searching raw genomic sequences, providing experimental confirmation or correction of predicted coding sequences, and has the potential to identify novel genes and elucidate splicing patterns.

PMID:
11780965
DOI:
10.1016/S0167-7799(01)01795-4
[Indexed for MEDLINE]

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