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Cell. 2001 Dec 28;107(7):827-30.

The unfolding tale of the unfolded protein response.

Author information

1
Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Abstract

Surface and secreted proteins are synthesized in the endoplasmic reticulum where they must fold and assemble before being transported. Changes in the ER that interfere with their proper maturation initiate the unfolded protein response pathway. New studies have filled in a missing link between the yeast and mammalian pathways.

PMID:
11779459
DOI:
10.1016/s0092-8674(01)00623-7
[Indexed for MEDLINE]
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