Send to

Choose Destination
See comment in PubMed Commons below
J Opt Soc Am A Opt Image Sci Vis. 2002 Jan;19(1):215-22.

Cone photopigment in older subjects: decreased optical density in early age-related macular degeneration.

Author information

Schepens Eye Research Institute and Harvard University, Boston, Massachusetts 02114, USA.


We measured changes to cone photoreceptors in patients with early age-related macular degeneration. The data of 53 patients were compared with normative data for color matching measurements of long- and middle-wavelength-sensitive cones in the central macula. A four-parameter model quantified cone photopigment optical density and kinetics. Cone photopigment optical density was on average less for the patients than for normal subjects and was uncorrelated with visual acuity. More light was needed to reduce the photopigment density by 50% in the steady state for patients. These results imply that cone photopigment optical density is reduced by factors other than slowed kinetics.

[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Optical Society of America Icon for PubMed Central
    Loading ...
    Support Center