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Science. 2002 Jan 4;295(5552):120-3.

Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q.

Author information

1
Department of Chemistry and Biochemistry, 607 Charles E. Young Drive East, Box 951569, University of California, Los Angeles, CA 90095, USA. larsen@chem.ucla.edu

Abstract

The isoprenylated benzoquinone coenzyme Q is a redox-active lipid essential for electron transport in aerobic respiration. Here, we show that withdrawal of coenzyme Q (Q) from the diet of wild-type nematodes extends adult life-span by approximately 60%. The longevity of clk-1, daf-2, daf-12, and daf-16 mutants is also extended by a Q-less diet. These results establish the importance of Q in life-span determination. The findings suggest that Q and the daf-2 pathway intersect at the mitochondria and imply that a concerted production coupled with enhanced scavenging of reactive oxygen species contributes to the substantial life-span extension.

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PMID:
11778046
DOI:
10.1126/science.1064653
[Indexed for MEDLINE]
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