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J Bioenerg Biomembr. 2000 Jun;32(3):237-46.

The catalytic mechanism of nucleoside diphosphate kinases.

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1
Institut de Biochimie et Génétique Cellulaires, UMR 5095 University of Bordeaux-2 and CNRS, France. ioan.lascu@ibgc.u-bordeaux2.fr

Abstract

Nucleoside diphosphate kinases catalyze the reversible transfer of the gamma phosphate of nucleoside triphosphates to nucleoside diphosphates. This minireview presents recent advances in understanding the reaction mechanism using steady-state and fast kinetic studies, X-ray crystallography, and site-directed mutagenesis. We also briefly discuss the physiological relevance of in vitro studies.

PMID:
11768307
[Indexed for MEDLINE]
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