Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell Mol Life Sci. 2001 Nov;58(12-13):1748-57.

The structure and function of nuclear lamins: implications for disease.

Author information

  • 1Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, Illinois 60611, USA. r-moir@northwestern.edu

Abstract

The nuclear lamins polymerize to form the nuclear lamina, a fibrous structure found on the inner face of the nuclear membrane. The lamins also appear to form structures within the nucleoplasm. These various lamin structures help to establish and maintain the shape and strength of the interphase nucleus, but recent work also suggests that the lamins have a role in nuclear processes such as DNA replication. Furthermore, mutations in the human lamin A/C gene have recently been linked to several diseases, including Emery-Dreifuss muscular dystrophy. This review discusses the nature of these mutations and the possible effects of lamin mutations on nuclear function.

PMID:
11766876
DOI:
10.1007/PL00000814
[PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center