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Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):303-8. Epub 2001 Dec 26.

Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer.

Author information

1
Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

Abstract

Targeting of the nuclear prostaglandin receptor peroxisome proliferator-activated receptor delta (PPARdelta) by homologous recombination results in placental defects and frequent (>90%) midgestation lethality. Surviving PPARdelta(-/-) mice exhibit a striking reduction in adiposity relative to wild-type levels. This effect is not reproduced in mice harboring an adipose tissue-specific deletion of PPARdelta, and thus likely reflects peripheral PPARdelta functions in systemic lipid metabolism. Finally, we observe that PPARdelta is dispensable for polyp formation in the intestine and colon of APC(min) mice, inconsistent with its recently proposed role in the establishment of colorectal tumors. Together, these observations reveal specific roles for PPARdelta in embryo development and adipocyte physiology, but not cancer.

PMID:
11756685
PMCID:
PMC117556
DOI:
10.1073/pnas.012610299
[Indexed for MEDLINE]
Free PMC Article

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