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Trends Parasitol. 2001 Dec;17(12):582-8.

Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?

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1
Department of Genetics, Box 357360, University of Washington, Seattle, WA 98195-7360, USA. sibley@genetics.washington.edu

Abstract

Chemotherapy remains the only practicable tool to control falciparum malaria in sub-Saharan Africa, where >90% of the world's burden of malaria mortality and morbidity occurs. Resistance is rapidly eroding the efficacy of chloroquine, and the combination pyrimethamine-sulfadoxine is the most commonly chosen alternative. Resistant populations of Plasmodium falciparum were selected extremely rapidly in Southeast Asia and South America. If this happens in sub-Saharan Africa, it will be a public health disaster because no inexpensive alternative is currently available. This article reviews the molecular mechanisms of this resistance and discusses how to extend the therapeutic life of antifolate drugs.

PMID:
11756042
[Indexed for MEDLINE]

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