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Bioorg Med Chem Lett. 2002 Jan 21;12(2):147-50.

Mixed lineage kinase activity of indolocarbazole analogues.

Author information

1
Kyowa-Hakko Kogyo Co., Ltd., Tokyo, Japan.

Abstract

The MLK1-3 activity for a series of analogues of the indolocarbazole K-252a is reported. Addition of 3,9-bis-alkylthiomethyl groups to K-252a results in potent and selective MLK inhibitors. The in vitro and in vivo survival promoting activity of bis-isopropylthiomethyl-K-252a (16, CEP-11004/KT-8138) is reported.

PMID:
11755341
DOI:
10.1016/s0960-894x(01)00690-4
[Indexed for MEDLINE]

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