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Immunity. 2001 Dec;15(6):997-1009.

Targeting the function of mature dendritic cells by human cytomegalovirus: a multilayered viral defense strategy.

Author information

1
Institute of Virology, Charité Medical School, Humboldt University Berlin, 10117 Berlin, Germany.

Abstract

Human cytomegalovirus (HCMV) can suppress and evade the immune system. We have identified as a mechanism the ability of HCMV to infect dendritic cells (DC), which initiate the antiviral immune response. HCMV-infected DC show enhanced expression of costimulatory molecules. In contrast, MHC molecules are partially downregulated, leading to a reduced antigen-presenting capacity. Moreover, the apoptosis-inducing ligands CD95L (FasL) and tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) are upregulated, thereby enabling HCMV-infected DC to delete activated T lymphocytes. This additional layer of viral defense is complemented by nondeletional mechanisms, which suppress surviving T cells. Thus, infection of DC allows the virus to blunt the antiviral T cell response by a multilayered defense strategy and could play a pivotal role in HCMV-triggered immunosuppression.

PMID:
11754820
DOI:
10.1016/s1074-7613(01)00239-4
[Indexed for MEDLINE]
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