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Nat Neurosci. 2002 Jan;5(1):19-26.

Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis.

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1
Department of Neurosciences, University of New Mexico Health Science Center, Albuquerque, New Mexico 87131, USA.

Abstract

Axon outgrowth during development and neurotransmitter release depends on exocytotic mechanisms, although what protein machinery is common to or differentiates these processes remains unclear. Here we show that the neural t-SNARE (target-membrane-associated-soluble N-ethylmaleimide fusion protein attachment protein (SNAP) receptor) SNAP-25 is not required for nerve growth or stimulus-independent neurotransmitter release, but is essential for evoked synaptic transmission at neuromuscular junctions and central synapses. These results demonstrate that the development of neurotransmission requires the recruitment of a specialized SNARE core complex to meet the demands of regulated exocytosis.

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PMID:
11753414
DOI:
10.1038/nn783
[Indexed for MEDLINE]

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