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Rheumatology (Oxford). 2001 Dec;40(12):1355-8.

The prevalence of Mycoplasma fermentans in patients with inflammatory arthritides.

Author information

1
Department of Genitourinary Medicine, Medicine A, Imperial College School of Medicine, St Mary's Campus, Paddington, London W2 1NY, UK.

Abstract

OBJECTIVES:

To search for evidence that Mycoplasma fermentans is involved in the pathogenesis of some forms of human arthritis by testing for the presence of mycoplasmal DNA in joint material.

METHODS:

M. fermentans DNA was detected by the identification of a 104-base pair amplification product of the polymerase chain reaction (PCR).

RESULTS:

M. fermentans DNA was detected in synovial fluid samples from six (17%) of 35 patients with rheumatoid arthritis (RA) and 18 (21%) of 85 patients with seronegative arthritis. These detection rates were significantly greater than in samples from patients with osteoarthritis or crystal synovitis, none of 26 of these being positive.

CONCLUSIONS:

M. fermentans could be involved in the pathogenesis of some forms of inflammatory arthritis and this possibility is worthy of further study.

PMID:
11752504
[Indexed for MEDLINE]

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