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Annu Rev Psychol. 2002;53:463-90.

Gene-environment interplay in relation to emotional and behavioral disturbance.

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Social, Genetic and Developmental Psychiatry Research Center, Institute of Psychiatry, London SE5 8AF, UK.


The conceptual and methodological issues involved in the study of gene-environment correlations (rGE) and interactions (GxE) are discussed in historical context. Quantitative genetic findings are considered with respect to rGE and GxE in relation to emotional and behavioral disturbance. Key conceptual and substantive implications are outlined in relation to both genetic and environmental risk mediation, with a brief note on evolutionary considerations.

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