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Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15067-72.

Siah-1 binds and regulates the function of Numb.

Author information

1
Molecular Engines Laboratories, 20 Rue Bouvier, 75011 Paris, France.

Abstract

The Drosophila Seven in absentia (Sina) gene product originally was described as a protein that controls cell fate decisions during eye development. Its mammalian homolog, Siah-1, recently was found to be involved in p53-dependent and -independent pathways of apoptosis and G(1) arrest. We report that Siah-1 interacts directly with and promotes the degradation of the cell fate regulator Numb. Siah-1-mediated Numb degradation leads to redistribution of endogenous cell-surface Notch to the cytoplasm and nucleus and to augmented Notch-regulated transcriptional activity. These data imply that through its ability to target Numb for degradation, Siah-1 can act as a key regulator of Numb-related activities, including Notch signaling.

PMID:
11752454
PMCID:
PMC64984
DOI:
10.1073/pnas.261571998
[Indexed for MEDLINE]
Free PMC Article

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