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J Virol. 2002 Jan;76(2):923-7.

Alpha/beta and gamma interferons are induced by infection with noncytopathic bovine viral diarrhea virus in vivo.

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1
Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom. bryan.charleston@bbsrc.ac.uk

Abstract

In contrast to the results of previous in vitro studies, experimental infection of calves with noncytopathic bovine viral diarrhea virus (ncpBVDV) was found to induce strong alpha/beta and gamma interferon responses in gnotobiotic animals. These responses were associated with depressed levels of transforming growth factor beta (TGF-beta) in serum. The results of this study indicate that the immunosuppression caused by ncpBVDV is not associated with low interferon responses or elevated levels of TGF-beta.

PMID:
11752182
PMCID:
PMC136826
[Indexed for MEDLINE]
Free PMC Article
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