Format

Send to

Choose Destination
EMBO Rep. 2002 Jan;3(1):76-81. Epub 2001 Dec 19.

The [URE3] phenotype: evidence for a soluble prion in yeast.

Author information

1
Centre de Génétique Moléculaire, 91190 Gif-sur-Yvette, France.

Abstract

The aggregation of the two yeast proteins Sup35p and Ure2p is widely accepted as a model for explaining the prion propagation of the phenotypes [PSI+] and [URE3], respectively. Here, we demonstrate that the propagation of [URE3] cannot simply be the consequence of generating large aggregates of Ure2p, because such aggregation can be found in some conditions that are not related to the prion state of Ure2p. A comparison of [PSI+] and [URE3] aggregation demonstrates differences between these two prion mechanisms. Our findings lead us to propose a new unifying model for yeast prion propagation.

PMID:
11751580
PMCID:
PMC1083930
DOI:
10.1093/embo-reports/kvf011
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center