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Curr Opin Struct Biol. 2001 Dec;11(6):685-93.

Structural insights into the regulation of bacterial signalling proteins containing PRDs.

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Architecture et Fonction des Macromolécules Biologique, UMR 6098 du CNRS, Université d'Aix-Marseille, I et II, ESIL-GBMA, 163 Avenue de Luminy Case 925, 13288 Cedex 9, Marseille, France.


PRD-containing proteins are bacterial transcriptional antiterminators and activators characterised by a duplicated phosphorylation domain involved in the regulation of catabolic operons. Recent genetic and biochemical studies have suggested how the activity of these regulators is positively or negatively controlled through the multiple phosphorylation of conserved histidyl residues. The regulation mode of these proteins has been examined in light of the recently determined first crystal structure of the phosphorylatable domain of the LicT antiterminator.

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