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Curr Biol. 2001 Dec 11;11(24):R1041-53.

Molecular genetic approaches to the targeted suppression of neuronal activity.

Author information

1
Molecular, Cellular, and Developmental Biology Department, Yale University, New Haven, Connecticut 06520, USA. Benjamin.White@Yale.edu

Abstract

Understanding how the diverse cells of the nervous system generate sensations, memories and behaviors is a profound challenge. This is because the activity of most neurons cannot easily be monitored or individually manipulated in vivo. As a result, it has been difficult to determine how different neurons contribute to nervous system function, even in simple organisms like Drosophila. Recent advances promise to change this situation by supplying molecular genetic tools for modulating neuronal activity that can be deployed in a spatially and temporally restricted fashion. In some cases, targeted groups of neurons can be 'switched off' and back 'on' at will in living, behaving animals.

PMID:
11747845
DOI:
10.1016/s0960-9822(01)00621-2
[Indexed for MEDLINE]
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