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Bioessays. 2001 Dec;23(12):1138-47.

The JAK/STAT pathway and Drosophila development.

Author information

1
The Cardiovascular Research Institute, Division of Molecular Cardiology, The Texas A&M University System Health Science Center, College of Medicine, Temple, Texas 76504, USA. hluo@medicine.tamu.edu

Abstract

The JAK/STAT signal transduction pathway plays a critical role in mammalian cells, particularly in hematopoiesis and immune responses. Several components of this pathway have been identified and characterized in Drosophila. Mutational analyses of these components have revealed a number of interesting developmental roles, and provide a mechanism to identify other interacting molecules and pathways. Hence, the JAK/STAT pathway in Drosophila serves as an attractive model for in vivo functional analyses of JAK/STAT signaling.

PMID:
11746233
DOI:
10.1002/bies.10016
[Indexed for MEDLINE]

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