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Bioessays. 2001 Nov;23(11):981-6.

Hindbrain patterning revisited: timing and effects of retinoic acid signalling.

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1
Department of Biology, University of Konstanz, Germany. gerrit.begemann@uni-konstanz.de

Abstract

Retinoids play a critical role in patterning, segmentation, and neurogenesis of the posterior hindbrain and it has been proposed that they act as a posteriorising signal during hindbrain development. Until now, direct evidence that endogenous retinoid signalling acts through a gradient to specify cell fates along the anteroposterior axis has been missing. Two recent studies tested the requirement for retinoid signalling in the developing hindbrain through systematic application of a pan-retinoic acid receptor antagonist. They demonstrate a stage-dependent requirement for increasing retinoid signalling activity along the hindbrain that proceeds from anterior to posterior. Together these findings challenge the concept of a stable gradient of retinoic acid across the hindbrain and warrant a re-interpretation of the phenotypes obtained by genetic and nutritional disruption of retinoid signalling in the amniote embryo.

PMID:
11746213
DOI:
10.1002/bies.1142
[Indexed for MEDLINE]
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