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J Pediatr. 2001 Dec;139(6):838-43.

Visceral hyperalgesia in children with functional abdominal pain.

Author information

1
Division of Gastroenterology, Departments of Pediatrics and Medicine, University of Pittsburgh School of Medicine, Pennsylvania, USA.

Abstract

OBJECTIVE:

Our purpose was to evaluate visceral sensitivity and psychologic profiles in children with functional gastrointestinal disorders.

STUDY DESIGN:

We measured visceral perception in the stomach and in the rectum by using an electronic barostat. Psychologic questionnaires were completed. Ten children with recurrent abdominal pain (RAP)(8 female, mean age 11.3 +/- 0.8 years), 10 children with irritable bowel syndrome (IBS) (8 female, mean age 13.0 +/- 0.9 years), and 15 control children (8 female, mean age 12.7 +/- 1.2 years) completed the study.

RESULTS:

Thresholds for visceral perception in the rectum were decreased in patients with IBS (P <.001 vs control patients) and in patients with RAP (P <.05 vs control patients). Children with IBS had lower thresholds than children with RAP (P <.01). In contrast, thresholds for perception were decreased in the stomach of children with RAP (P <.005 vs control patients) but not in children with IBS. There were elevated anxiety scores in 45% of patients. Duration of symptoms was associated with higher scores of anxiety (P <.001) and depression (P <.02).

CONCLUSIONS:

Hyperalgesia was demonstrated in children with RAP and IBS; sites of hyperalgesia appear to be associated with different symptom phenotypes; anxiety was common, and there was an association between the duration of symptoms and increased scores for both anxiety and depression.

PMID:
11743510
DOI:
10.1067/mpd.2001.118883
[Indexed for MEDLINE]

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