Format

Send to

Choose Destination
See comment in PubMed Commons below
Obes Res. 2001 Dec;9(12):741-5.

Association of BMI with the beta3-adrenergic receptor gene polymorphism in Japanese: meta-analysis.

Author information

1
Department of Environmental Health Sciences, Tohoku University Graduate School of Medicine, Sendai, Japan. n-kuro@ehs.med.tohoku.ac.jp

Abstract

OBJECTIVE:

To assess the effect of the Trp64Arg polymorphism in the beta3-adrenergic receptor gene (ADRB3) on body mass index (BMI) in the Japanese population.

RESEARCH METHODS AND PROCEDURES:

We selected studies that evaluated the association between BMI and ADRB3 polymorphism among Japanese, using MEDLINE and PubMed. After data collection, an extension of ANOVA was performed to assess the differences according to the genotype.

RESULTS:

In a total of 35 subgroups including 2316 subjects with the Trp64Arg variant and 4266 subjects without this variant, the weighted mean difference in BMI was 0.26 kg/m(2) (95% confidence interval: 0.18 to 0.42; p < 0.01), indicating that variant carriers exhibited higher BMI than did normal homozygous subjects.

DISCUSSION:

Although it is known that the allele frequency of the ADRB3 polymorphism differs among races, this study focuses on the Japanese population, which has a high allele frequency of ADRB3 polymorphism. We assumed that statistical errors would be prevented due to the sufficient number of subjects. In conclusion, the results support the hypothesis that ADRB3 gene polymorphism is associated with BMI.

PMID:
11743057
DOI:
10.1038/oby.2001.102
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center