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Lancet. 2001 Dec 1;358(9296):1875-6.

Subcellular distribution of aquaporin 5 in salivary glands in primary Sjögren's syndrome.

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Department of Immunology, Allergy and Arthritis, Flinders Medical Centre, SA 5042, Bedford Park, Australia.


Secretions from salivary and lacrimal glands are reduced in patients with primary Sjögren's syndrome (PSS). Since aquaporin 5 is involved in transport of water and is present in salivary and lacrimal glands, this protein was thought to have a major role in the pathogenesis of PSS. We used indirect immunofluorescence and an immunoperoxidase technique to assess expression and subcellular localisation of aquaporin 5 in patients and controls. Our results suggest that the distribution and density of aquaporin 5 in salivary glands does not differ between patients with PSS and those without. Thus, the role of aquaporin 5 in the pathogenesis of PSS needs to be reassessed and alternative pathogenetic mechanisms investigated.

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