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Biochem Biophys Res Commun. 2001 Dec 21;289(5):1237-42.

Negative regulation of filamentous growth and flocculation by Lkh1, a fission yeast LAMMER kinase homolog.

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Department of Microbiology, Chungnam National University, Taejon, 305-764, Korea.


We have isolated a full-length cDNA clone that encodes for a Schizosaccharomyces pombe homolog of the dual-specificity protein kinase of the LAMMER family, lkh1 (lammer kinase homolog). The proposed Lkh1 protein contains 575 amino acids. The lkh1(+) null mutant is viable, but exhibits flocculation upon reaching stationary phase in liquid media and filamentous adhesion growth on solid media. Analysis of the flocculation activity of the lkh1(+) null mutant indicates that asexual aggregation of S. pombe cells into floccules is divalent cation-dependent and galactose-specific. We also demonstrate that the Saccharomyces cerevisiae LAMMER kinase homolog, Kns1, can substitute for the Lkh1 function in S. pombe.

[Indexed for MEDLINE]

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