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AIDS. 2001 Dec 7;15(18):2441-4.

Failure to maintain long-term adherence to highly active antiretroviral therapy: the role of lipodystrophy.

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INSERM U379, Marseille, France.


In a sample of 277 patients included in the French APROCO cohort study who were initially adherent at follow-up visit 4 months after initiation of a protease inhibitor-containing regimen, 76.4% self-reported at least one lipodystrophy-related symptom and 30.0% failed to maintain adherence behaviour 20 months after enrolment. After multiple adjustment for other related factors, such as younger age, alcohol consumption and poor housing conditions, the number of self-reported lipodystrophy symptoms was independently associated with adherence failure.

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