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Neurology. 2001 Dec 11;57(11):2108-11.

Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: a pilot study.

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Department of Neurology, Manchester Royal Infirmary, UK.


The lateral segment of the globus pallidus (GPl) is thought to be overactive in levodopa-induced dyskinesia in PD. Stimulation of cannabinoid receptors in the GPl reduces gamma-aminobutyric acid (GABA) reuptake and enhances GABA transmission and may thus alleviate dyskinesia. In a randomized, double-blind, placebo-controlled, crossover trial (n = 7), the authors demonstrate that the cannabinoid receptor agonist nabilone significantly reduces levodopa-induced dyskinesia in PD.

[Indexed for MEDLINE]

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