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Trends Immunol. 2001 Dec;22(12):677-82.

Death-receptor contribution to the germinal-center reaction.

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Department of Cell Biology and Histology, Cellular Immunology Group, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands.


Both helper T cells and follicular dendritic cells play crucial roles in the germinal-center (GC) reaction. One of their key functions is to provide GC B cells with anti-apoptotic signals during their growth, diversification of antibody repertoire and positive selection. Dysregulation of the mechanisms that control B-cell apoptosis in the GC could cause hyperplasia, endanger self-tolerance or impair dramatically the efficiency of the humoral response. This article discusses how the death receptor Fas and components of its signaling machinery contribute to the GC reaction.

[Indexed for MEDLINE]

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