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J Cataract Refract Surg. 2001 Dec;27(12):1969-74.

Human aqueous humor levels of oral ciprofloxacin, levofloxacin, and moxifloxacin.

Author information

1
Fundación Hospital Alcorcón, Madrid, Spain. mcgarcias@fhalcorcon.es

Abstract

PURPOSE:

To evaluate the penetration of ciprofloxacin, levofloxacin, and moxifloxacin into the aqueous humor after oral administration.

SETTING:

Alcorcon Hospital, Madrid, Spain.

METHODS:

Forty-two patients having cataract surgery were randomly divided into 3 groups the day before surgery. The first group received 2 oral 500 mg doses of ciprofloxacin at 12-hour intervals. The second group received a single oral 500 mg dose of levofloxacin. The third group received a single oral 400 mg dose of moxifloxacin. At the time of surgery, 0.1 mL aqueous fluid was aspirated from the anterior chamber just before the operation and immediately stored at -80 degrees C. Drug concentrations were measured using a biological assay.

RESULTS:

The mean aqueous level of ciprofloxacin was 0.50 microg/mL +/- 0.25 (SD); of levofloxacin, 1.50 +/- 0.50 microg/mL; and of moxifloxacin, 2.33 +/- 0.85 microg/mL. The mean aqueous levels of levofloxacin and moxifloxacin were above the 90% minimum inhibitory concentration for most of the common microorganisms that cause endophthalmitis.

CONCLUSIONS:

Therapeutic concentrations of fluoroquinolones, mainly levofloxacin and moxifloxacin, were reached with oral administration. These antibiotics may be effective for prophylaxis and adjuvant therapy of bacterial endophthalmitis.

PMID:
11738912
DOI:
10.1016/s0886-3350(01)00997-x
[Indexed for MEDLINE]

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